| 发明名称 |
METHOD OF ISOLATING INGENOL |
| 摘要 |
The present invention relates to a new method for isolating ingenol (C20H28O5) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate. |
| 申请公布号 |
US2014243551(A1) |
申请公布日期 |
2014.08.28 |
| 申请号 |
US201214348750 |
申请日期 |
2012.10.02 |
| 申请人 |
INDENA S.P.A. |
发明人 |
Bellido Cabello De Alba Maria Luz;Appendino Giovanni;Pagani Alberto;Munoz Blanco Eduardo |
| 分类号 |
C07C67/60 |
主分类号 |
C07C67/60 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of isolating ingenol from a mixture of diterpenoid esters and ingenol esters said method comprising:
combining diterpenoid esters and ingenol esters to obtain a mixture; combining phases of hydrolyzing ingenol present in said mixture and isolating ingenol from said mixture in a single step. |
| 地址 |
Milano IT |
