| 摘要 |
The present invention relates to: a novel α,&bgr;-unsaturated amide compound; a method for preparing a composition for preventing or treating obesity, comprising the steps of selecting a compound showing an obesity prevention or treatment effect from a compound library comprising one or more α,&bgr;-unsaturated amide compounds, and preparing a composition for preventing or treating obesity containing the selected compound; and a composition for preventing or treating obesity, containing an α,&bgr;-unsaturated amide compound. The α,&bgr;-unsaturated amide compound of the present invention has a mother nucleus structure mimicking a piper amide, which is a natural substance showing various activities, and can show various pharmacological activities. In addition, a pure compound can be obtained without carrying out a purification process by column chromatography normally used since soluble by-products are generated using &bgr;-phosphono-N-hydroxysuccinimidyl ester as an intermediate. Additionally, it is possible to screen a compound, which is a BRS-3 agonist, from a library of the compound synthesized thereby through a pharmacological activity test, and utilize the same in a composition for preventing or treating obesity. |
