The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

摘要

THE USE OF FENOTEROL AND FENOTEROL ANALOGUES IN THE TREATMENT OF GUOBLASTOMAS AND ASTROCYTOMAS This disclosure concerns the discovery of the use of fenoterol and (R;R)- and {RS) fenoterol analogues for the treatment of a tumor expressing a p2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a 02 adrenergic receptor, In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject. %45230iG ~ F14s) PS9AV1 MAREE Wna r ci R Nj t i '~1 QC ~fl CI' ~N 0 00 N 0 N p.