The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic siRNAs and miRNAs.
申请公布号
WO2014130945(A1)
申请公布日期
2014.08.28
申请号
WO2014US18015
申请日期
2014.02.24
申请人
INTEGRATED DNA TECHNOLOGIES, INC.;BEHLKE, MARK, AARON;LENNOX, KIMBERLY, ANN;JACOBI, ASHLEY, MAE;OWCZARZY, RICHARD;WALDER, JOSEPH, ALAN
发明人
BEHLKE, MARK, AARON;LENNOX, KIMBERLY, ANN;JACOBI, ASHLEY, MAE;OWCZARZY, RICHARD;WALDER, JOSEPH, ALAN
