| 发明名称 |
METHOD FOR MEASURING BETA-LACTAM ANTIBIOTICS |
| 摘要 |
The present invention relates to methods for determining the concentration of a free beta-lactam antibiotic in a biological sample. In particular, the present invention relates to methods for measuring a free beta-lactam antibiotic in a biological sample, comprising the steps of: (a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining the concentration of said free beta-lactam antibiotic in said at least one biological sample. |
| 申请公布号 |
US2014243241(A1) |
申请公布日期 |
2014.08.28 |
| 申请号 |
US201214350646 |
申请日期 |
2012.10.15 |
| 申请人 |
UNIVERSITE DE LIEGE ;UNIVERSITE CATHOLIQUE DE LOUVAIN ;UNIVESITE LIBRE DE BRUXELLES ;UNIVERSITE DE MONS |
发明人 |
Brans Alain;Joris Bernard;Delmarcelle Michael;Marchand Jacqueline;Tulkens Paul;Hammaecher Catherine;Goormaghtigh Erik;De Coninck Joel |
| 分类号 |
C12Q1/34;C12N9/86 |
主分类号 |
C12Q1/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining the concentration of a free beta-lactam antibiotic in a biological sample, comprising the steps of:
(a) providing at least one class C beta-lactamase, a functional fragment or variant thereof; (b) providing at least one biological sample; (c) contacting said at least one class C beta-lactamase with said at least one biological sample; and (d) determining said concentration of said free beta-lactam antibiotic in said at least one biological sample. |
| 地址 |
Angleur BE |
