METHOD FOR EXTRACTING ARTERIAL INPUT FUNCTION AND APPLICATION THEREOF TO DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING

摘要

The present invention discloses a method for extracting AIF and an application thereof to DCE-MRI. The method comprises steps: contacting a target tissue with a contrast agent to obtain a plurality of images; using the plurality of images to work out the tissue concentration curve of the contrast agent in each voxel; calculating the purity of the tissue concentration curve of each voxel according to the tissue concentration curves; and extracting the voxel having the highest purity as the optimized arterial location; and extracting the tissue concentration curve of the voxel having the highest purity as the arterial input function. The extracted AIF is applied to a pharmacokinetic model to obtain associated pharmacokinetic parameters. The present invention not only improves the accuracy and reliability of the derived quantitative indexes but also promotes the efficiency of the quantitative analysis.

主权项

1. A method for extracting an arterial input function, comprising steps:
Step (a): contacting a target tissue with a contrast agent to obtain a plurality of images; Step (b): using said plurality of images to work out a time intensity curve of said contrast agent in each voxel; Step (c): using said time intensity curve to calculate a purity of said time intensity curve of each voxel; and Step (d): selecting said time intensity curve of a voxel having the highest purity in step (c) as an arterial input function.