ANTIBODY TO OX-2/CD200 AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide agents and methods for modulating the function of CD200.SOLUTION: Disclosed are agents for modulating the function of CD200, and the agents include modulating agents for the activity and/or expression of CD200 and/or its receptor (CD200R). In some embodiments, the agents inhibit the function or activity of CD200. Thus in certain aspects, the agents act as antagonists to CD200. Certain antagonists may bind to CD200 and inhibit or disrupt the interaction of CD200 with its receptor. Other antagonists may bind to CD200 but may not block the CD200:CD200R interaction. Thus CD200 antagonists include any agent that is capable of modulating the effects of CD200 by mechanisms that may or may not include blocking the CD200:CD200R interaction.