Composition with Sustained Antimicrobial Activity

摘要

Disclosed herein are compositions comprising benzyl alcohol, one or more cationic antimicrobial agent, and one or more emollient, the combination of which results in persistent antimicrobial activity after application to the skin. The compositions optionally further comprise an organic acid and/or a zinc salt, such as zinc gluconate, as an anti-irritant.

主权项

1. A composition for topical application comprising:
(i) benzyl alcohol at a concentration of between about 0.1 and about 5% w/w; (ii) one or more cationic antimicrobial agent selected from the group consisting of a quaternary ammonium compound, a biguanide, and a combination thereof, wherein the quaternary ammonium compound, if present, is at a concentration of between about 0.05 and about 1% w/w and the biguanide, if present, is at a concentration of between about 0.05 to about 3.0% w/w; and (iii) one or more emollient selected from the group consisting of dipropylene glycol, farnesol, and combinations thereof, at a concentration effective in producing persistent antimicrobial activity after application to the skin.