PHARMACEUTICAL COMPOSITIONS HAVING DESIRABLE BIOAVAILABILITY

摘要

The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil.

主权项

1. An ophthalmic pharmaceutical composition, comprising:
a pharmaceutical vehicle suitable for topical application to an eye of a human; an amount of therapeutic agent suitable for treating the eye; an effectively low amount of surfactant sufficient for providing a high degree of bioavailability of the therapeutic agent, wherein: i. the amount of surfactant is below about 0.4 w/v % of the composition; ii. the surfactant includes ethoxylated and/or hydrogenated vegetable oil; iii. the therapeutic agent includes a prostaglandin; and iv. the pharmaceutical vehicle includes water.