Phenyl Carboxamide-Containing Spleen Tyrosine Kinase (SYK) Inhibitors

摘要

The invention provides certain phenyl carboxamide-containing compounds of the Formula (I); or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.;

主权项

1. A compound of the Formula (I)or a pharmaceutically acceptable salt thereof, wherein
B is pyridyl or quinolinyl;
wherein B is unsubstituted or substituted by 1 to 3 R3 moieties, wherein each R3 moiety is independently selected from the group consisting of: C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluoroalkyl, C1-C3 hydroxyalkyl, halo, hydroxy, amino, (C1-C3 alkyl)amino, di(C1-C3 alkyl)amino, and E;
wherein E is phenyl, a 5- or 6-membered heteroaryl containing 1 to 3 N atoms, or a 6-membered heterocyclyl containing 1 to 2 heteroatoms selected from the group consisting of N and O;
wherein E is unsubstituted or substituted by 1 to 2 moieties independently selected from the group consisting of C1-C3 alkyl, C1-C3 alkoxy, and halo; A is  wherein
Y is —CH2— or —O—;R11 and R12 are independently H or F; andn′ is 0 or 1.