NOVEL SMALL MOLECULE INHIBITORS OF BIOFILM FORMATION AND THE NOVEL USE OF PREVIOUSLY IDENTIFIED COMPOUNDS FOR INHIBITION OF BIOFILM FORMATION AND APPLICATIONS FOR DRUG THERAPY AND MEDICAL DEVICE COATING

摘要

Novel compounds and the novel use a class of previously identified small molecules for the inhibition of biofilm formation. Inhibition of biofilm formation can play a very important role in contributing to pathogenicity. Bacteria in the biofilm state have been shown to be 10-10,000-fold less susceptible to antibiotic treatment. Estimations made by the Centers for Disease Control (CDC) and the National Institutes of Health (NIH) attribute 65% to 80% of human infections as biofilm mediated. Consequently, biofilm formation is often responsible for chronic infections due to bacterial persistence despite antibiotic treatment.