A homogenous, symmetrically dividing population of adherent neural stem cells is obtained from ES cells or foetal or adult brain isolates, using an activator of a signalling pathway downstream of a receptor of the EGF receptor family, optionally in combination with an activator of a signalling pathway downstream of an FGF receptor. The neural stem cell population is highly pure and retains the ability to differentiate into neurons after in excess of 100 passages.
申请公布号
WO2005121318(A8)
申请公布日期
2014.08.28
申请号
WO2005GB02289
申请日期
2005.06.09
申请人
THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH;CONTI, LUCIANO;POLLARD, STEVEN, MICHAEL;SMITH, AUSTIN, GERARD