BISPECIFIC ANTIBODY

摘要

Provided are bispecific antibodies comprised of a single-chain unit having specificity to an immune cell and a monovalent unit having specificity to a tumor cell or a microorganism. The single-chain unit includes a single-chain variable fragment (scFv) fused to an Fc fragment and the monovalent unit includes a light chain and heavy chain pair. Also provided are methods of preparing bispecific antibodies and pharmaceutical and diagnostic uses of these antibodies.

主权项

1. An antibody comprising:
(a) a monovalent unit comprising a light chain-heavy chain pair having specificity to a tumor cell or a microorganism; and (b) a single-chain unit comprising a fusion peptide comprising a single-chain variable fragment (scFv) and an Fc fragment comprising a CH2 domain and a CH3 domain, wherein the fusion peptide has specificity to an immune cell.