摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compound of formulaor to its therapeutically acceptable salt, where Arepresents N or C(A); Arepresents H; Brepresents H, ORor NHR; Drepresents H; Erepresents H; Yrepresents CN, NO, F, Cl, Br, I, Ror SOR; Rrepresents Ror R; Zrepresents Ror R; Zrepresents R; Zand Zboth are absent; Lrepresents R; Rrepresents phenylene; Rrepresents indolyl; Rrepresents piperasinyl; Rrepresents R; Rrepresents C-Calkylene; Zrepresents R, Ror R; Rrepresents phenyl; Rrepresents benzodioxilyl; Rrepresents C-Ccycloalkenyl, heterocycloalkyl, which represents monocyclic six- or seven-member ring, containing one heteroatom, selected from O, and zero of double bonds, or azaspiro[5.5]undec-8-ene; the remaining values of radicals are given in i.1 of invention formula. Invention also relates to pharmaceutical composition, based on claimed compound.EFFECT: novel compounds, which can be applied in medicine for treatment of diseases, in the process of which anti-apoptotic Bcl-2 protein is expressed, are obtained.8 cl, 2 tbl, 411 ex |