2,4-DIAMINE-PYRIMIDINE DERIVATIVES AS SERINE/THREONINE KINASE INHIBITORS

摘要

Compounds having the formula I wherein A, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, Ra, Rb, X1, X2, X3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders.