发明名称 |
Compositions for the therapy of bcl2-associated cancers |
摘要 |
The invention provides an miR gene product which comprises a a nucleotide sequence that is complementary to nucleotides 3741-3749 of SEQ ID NO:55 and which is miR-15a or miR-16-1 for use in treating a cancer associated with overexpression of a BCL2 gene product in a subject, wherein the use comprises administering an effective amount of the miR gene product. The subject may be a human. The cancer may be chronic lymphocytic leukemia (CLL), lymphoma or lung cancer. If the cancer is lymphoma, the lymphoma may be selected from follicular lymphoma, large cell lymphoma and non-Hodgkin's lymphoma. If the cancer is lung cancer, the lung cancer may be non-small cell lung carcinoma. |
申请公布号 |
EP1937280(B1) |
申请公布日期 |
2014.08.27 |
申请号 |
EP20060814375 |
申请日期 |
2006.09.11 |
申请人 |
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
CROCE, CARLO, M.;CALIN, GEORGE, A. |
分类号 |
A61K31/7088;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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