摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to 2,5 substituted arylsulphonamides of formula (Ia) or to their pharmaceutically acceptable salts, solvates, hydrates, stereoisomers or tautomers, where X represents S, SO or SO; Y and Z represents (i) Y represents NR; and Z represents =O, CORor Calkyl; or (ii) Y represents CH, CHF, CHCH, O, S or SO; and Z represents hydrogen or Calkyl; Rand Reach independently represents halogen, Calkyl or Chalogenalkyl; Rrepresents CN or NO; Rrepresents hydrogen or Calkyl; Rrepresents hydrogen or Calkyl; and Rrepresents hydrogen or Calkyl. Invention also relates to compounds of formula (I) and (II), values of radicals of which are given in the invention formula, specific compounds, pharmaceutical composition based on compound of formula,and,method of modulating CCR3 activity.EFFECT: obtained are novel compounds, possessing useful biological properties.18 cl, 1 tbl, 3 ex |