发明名称 NEW BICYCLIC DIHYDROISOQUINOLINE-1-ONE DERIVATIVES
摘要 The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, A1, A2, A3, A4, A5 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful, for example, as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.
申请公布号 KR20140104000(A) 申请公布日期 2014.08.27
申请号 KR20147018023 申请日期 2012.11.27
申请人 F. HOFFMANN-LA ROCHE AG 发明人 AEBI JOHANNES;AMREIN KURT;CHEN WENMING;HORNSPERGER BENOIT;KUHN BERND;LIU YONGFU;MAERKI HANS P.;MAYWEG ALEXANDER V.;MOHR PETER;TAN XUEFEI;WANG ZHANGUO;ZHOU MINGWEI
分类号 C07D401/04;A61K31/4375;A61P9/12;C07D217/22;C07D401/14 主分类号 C07D401/04
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