SUBSTITUTED PIRIDAZINE-CARBOXAMIDE COMPOUNDS AS KINASE-INHIBITING COMPOUNDS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to piridazine derivatives of formula II,in which radicals and symbols have determinations, given in the invention formula, or to their pharmaceutically acceptable salts.EFFECT: compounds of formula II demonstrate inhibiting effect with respect to proteinkinases such as c-met, ron, or ALK, or chimeric proteins, and can be useful for treatment of disorders, associated with abnormal activity of proteinkinases, such as cancer.7 cl, 1 tbl, 30 ex