发明名称 |
Plasma kallikrein binding proteins |
摘要 |
Plasma kallikrein binding proteins and methods of using such proteins are described. |
申请公布号 |
US8816055(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US201213345170 |
申请日期 |
2012.01.06 |
申请人 |
Dyax Corp. |
发明人 |
Sexton Daniel J.;Viswanathan Malini |
分类号 |
A61K39/395;C07K16/40;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
主权项 |
1. An isolated antibody that binds to the active form of human plasma kallikrein, wherein the antibody comprises:
a heavy chain variable region comprising a complementary determining region (CDR) 1 set forth as HYIMM (SEQ ID NO: 166), a CDR2 set forth as GIYSSGGITVYADSVKG (SEQ ID NO: 167), and a CDR3 set forth as RRIGVPRRDEFDI (SEQ ID NO: 1171); and a light chain variable region comprising a CDR1 set forth as RASQSISSWLA (SEQ ID NO: 1172), a CDR2 set forth as KASTLES (SEQ ID NO: 1173), and a CDR3 set forth as QQYNTYWT (SEQ ID NO: 1174). |
地址 |
Burlington MA US |