Heterocyclyl-pyridinyl-based biphosphonic acid, pharmaceutically acceptable salt thereof, composition thereof and method of use thereof

摘要

The present invention relates to novel compounds, compositions containing same and methods for inhibiting human farnesyl pyrophosphate synthase or for the treatment or prevention of disease conditions using said compounds;;

主权项

1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted 3-11 membered heterocycle or an optionally substituted C6-10 aryl; W is CH or N; X is each independently CR10R11 or NR10, and wherein X is connected to a carbon atom of the ring; R1 is H, OH, or F; each R2 is hydrogen, or a substituent independently selected from halogen, amino, amido, cyano, hydroxyl, C1-6alkyl, C6-10aryl, C1-6alkoxy, C6-10aryloxy, 3-10 membered heterocycle, —C(O)R24, —C(O)OR24, —NR25C(O)R26 and —SO2NR24R27; R10 and R11 are each independently H or C1-6 alkyl; R24 and R27 are each independently H, C1-6 alkyl, C6-10 aryl, C6-10aryl-C1-6alkyl or 3-10 membered heterocycle; R25 is H or C1-6 alkyl; and R26 is each independently H, C1-6 alkyl, C6-10 aryl, C6-10aryl-C1-6alkyl or 3-10 membered heterocycle; or R25 and R26 are taken together with the atoms to which they are attached to form a 3 to 10 membered heterocycle.