| 摘要 |
There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof. |
| 主权项 |
1. A compound of Formula 1: or a pharmaceutically acceptable salt thereof, wherein - - - denotes an optional bond forming a cyclic moiety; R1 and R2 are H—, or R1 and R2 are taken together with the phenyl to form benzo[d][1,3]oxazin-2-one moiety; X1 is one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C1-C6 alkyl, fluoro, chloro, bromo, straight- or branched-chain C1-C6 alkoxy, nitro, dimethylamino and trifluoromethyl, or X1 is taken together with the phenyl to form naphthyl or methylenedioxyphenyl; z is H— or fluoro; Ar is selected from the group consisting of phenyl, pyridinyl, pyrimidinyl, naphthyl, dihydrobenzodioxinyl, methylenedioxyphenyl and quinoxalinyl, wherein each of phenyl, pyridinyl and pyrimidinyl is optionally substituted by one or more substituents independently selected from the group consisting of H-, straight- or branched-chain C1-C6 alkyl, hydroxy, halo, straight- or branched-chain C1-C6 alkoxy, nitro, acetyl, t-butylacetyl, trifluoromethyl, trifluoromethoxy, amino, benzyloxy, t-butylcarbonyloxy, benzyloxycarbonyloxy, ethanoyloxy, and cyclopentyloxy; each of Y1, Y2 and Y4 is independently H— or methyl; Y3 is H— or phenyl; n is 1 or 2; and m is 0 or 1. |
