发明名称 |
Aglycosylated immunoglobulin mutants |
摘要 |
The present invention is based, in part, on our discovery of immunoglobulins (e.g., immunoglobulin G (IgG)) polypeptides (e.g., murine or human IgG, such as human IgG1) that are aglycosylated yet retain the ability to bind to an Fc receptor, such as an activating Fc receptor (e.g., FcγRIIA and/or FcγRIIIA). |
申请公布号 |
US8815237(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US200812746411 |
申请日期 |
2008.12.05 |
申请人 |
Massachusetts Institute of Technology;The Rockefeller University |
发明人 |
Wittrup K. Dane;Ravetch Jeffrey;Sazinsky Stephen Lael |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
Hamilton, Brook, Smith & Reynolds, P.C. |
代理人 |
Hamilton, Brook, Smith & Reynolds, P.C. |
主权项 |
1. An IgG antibody comprising a first mutation in the C′/E loop of the CH2 domain of the Fc region that eliminates antibody glycosylation in the CH2 domain and a second mutation in the F/G loop of the CH2 domain, wherein the antibody exhibits at least 50% binding activity to activating receptor FcγRIIA or FcγRIIIA, relative to the corresponding wild type antibody, wherein the mutation in the F/G loop of the CH2 domain comprises K326I. |
地址 |
Cambridge MA US |