发明名称 |
METHOD FOR PURIFYING RECOMBINANT FSH |
摘要 |
The present invention relates to a method for purifying a recombinant follicle stimulating hormone (FSH) or recombinant FSH variant. The method comprises the steps of subjecting a liquid containing a recombinant FSH or recombinant FSH variant to an anion exchange chromatography, to a hydrophobic interaction chromatography, and to a dye affinity chromatography, wherein these chromatographies may be performed in any order, and wherein the method neither comprises a weak anion exchange chromatography nor a reverse phase chromatography. The method of purification results in a high yield of recombinant FSH having a desired degree of purity. The obtained FSH is especially useful for the prophylaxis and treatment of disorders and medical indications where FSH preparations are considered as useful remedies. |
申请公布号 |
UA106369(C2) |
申请公布日期 |
2014.08.26 |
申请号 |
UA20110012796 |
申请日期 |
2010.04.01 |
申请人 |
RATIOPHARM GMBH |
发明人 |
SCHECKERMANN, CHRISTIAN;EICHINGER, DIETMAR;ARNOLD, STEFAN |
分类号 |
C07K1/18;A61K38/04;C07K1/20;C07K14/59 |
主分类号 |
C07K1/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|