发明名称 |
1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO [3, 4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS |
摘要 |
The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), in which is a tetrahydropyranyl-group and Ris the group V-W-*, whereby V and W independently of each other may be an aryl group or an heteroaryl group, which independently of each other may optionally be substituted. According to one aspect of the invention the new compounds are for use as medicaments or for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments and/or for use in the treatment of e.g. Alzheimer's disease, in particular for cognitive impairment associated with Alzheimer's disease. |
申请公布号 |
UA106368(C2) |
申请公布日期 |
2014.08.26 |
申请号 |
UA20110012305 |
申请日期 |
2010.03.26 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
GIOVANNINI, RICCARDO;DORNER-CIOSSEK, CORNELIA;EICKMEIER, CHRISTIAN;FIEGEN, DENNIS;FOX, THOMAS;FUCHS, KLAUS;HEINE, NIKLAS;ROSENBROCK, HOLGER;SCHAENZLE, GERHARD |
分类号 |
C07D487/04;A61K31/519 |
主分类号 |
C07D487/04 |
代理机构 |
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