Treatment of amyloidoses using myelin basic protein and fragments thereof

摘要

In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral amyloid angiopathy (“CAA”). Some embodiments provide methods of identifying additional interfering fragments. Others provide methods of identifying substances that modulate the interference. Further embodiments provide methods of preventing amyloidoses, especially AD and CAA by administering myelin basic proteins or fragments thereof.

主权项

1. A peptide consisting of a myelin basic protein fragment, wherein said fragment consists of the amino acid sequence KRGX1X2X3X4X5X6HP (SEQ ID NO:1), wherein X1-X6 are amino acids selected from the group consisting of G, P, A, V, L, I, M, C, F, Y, W, H, K, R, Q, N, E, D, S and T.