Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers

摘要

Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.

主权项

1. A liquid cyanoacrylate tissue adhesive/sealant formulation comprising:
a mixture of n-butyl cyanoacrylate and methoxypropyl cyanoacrylate or ethyl cyanoacrylate and methoxypropyl cyanoacrylate at a weight ratio ranging between 50/50 and 90/10; at least one carboxylic acid-bearing C-succinylated heterochain polymeric modifier which is a triaxial segmented copolyester comprising ε-caprolactone, trimethylene carbonate, l-lactide, and glycolide in a molar ratio of 35/14/34/17, the triaxial segmented copolyester being made by the step of reacting the triaxial segmented copolyester with maleic anhydride under free-radical conditions to introduce succinic anhydride side groups onto the main chain and half-ester end-groups, followed by the step of selective hydrolysis of the anhydride side group to yield succinic acid side groups; at least 2 ppm of an acidic or acid producing compound; less than 1000 ppm of a free-radical scavenger; and wherein the C-succinylated heterochain polymeric modifier is capable of increasing the viscosity of the liquid formulation by at least 5 percent relative to the mixture of n-butyl cyanoacrylate and methoxypropyl cyanoacrylate or ethyl cyanoacrylate and methoxypropyl cyanoacrylate alone, shielding against premature anionic polymerization of cyanoacrylate monomers, and increasing the compliance of the cured formulation.