发明名称 |
Substituted oxindole derivatives and their use as vasopressin receptor ligands |
摘要 |
The present invention relates to novel oxindole derivatives of the general formula (I);
to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases. |
申请公布号 |
US8815868(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US200712521713 |
申请日期 |
2007.12.28 |
申请人 |
Abbott GmbH & Co. KG |
发明人 |
Netz Astrid;Oost Thorsten;Geneste Herve;Braje Wilfried;Wernet Wolfgang;Unger Liliane;Hornberger Wilfried;Lubisch Wilfried |
分类号 |
A61K31/496;A61K31/4545;C07D401/04;C07D401/14 |
主分类号 |
A61K31/496 |
代理机构 |
Michael Best & Friedrich LLP |
代理人 |
Mueller Lisa V.;Michael Best & Friedrich LLP |
主权项 |
1. A compound of the general formula (I)in which
R1 is ethoxy; R2 is hydrogen; R3 is cyano; R4 is hydrogen; R5 is hydrogen, methoxy or ethoxy; R6 is hydrogen or methoxy; R7 is hydrogen, methyl, ethyl, n-propyl or isopropyl; X1 is —NH—; X2 is N or CH; X3 is N or CH; where X2 and X3 are not simultaneously N;and the pharmaceutically acceptable salts, and tautomeric forms thereof. |
地址 |
Wiesbaden DE |