Transdermal drug delivery device including an occlusive backing

摘要

A transdermal drug delivery system for the topical application of one or more active agents contained in one or more polymeric and/or adhesive carrier layers, proximate to a non-drug containing polymeric backing layer which can control the delivery rate and profile of the transdermal drug delivery system by adjusting the moisture vapor transmission rate of the polymeric backing layer.

主权项

1. A method for transdermally delivering a drug to a user in need thereof over an extended period of at least three days, comprising administering to said user a transdermal drug delivery system comprising:
(a) a carrier composition comprising a pressure sensitive adhesive and a therapeutically effective amount at least one drug for transdermal drug delivery, and (b) an occlusive backing layer, wherein said occlusive backing layer is formed of a plurality of layers and comprises a first layer formed from a material selected from the group consisting of acrylonitrile, cellulose acetate, polycarbonate, ethylene vinyl acetate, ethylene methyl acrylate, polyester, polyethylene, polypropylene, polystyrene, polyurethane, polyvinyl alcohol, ethylene vinyl alcohol, polyamides, polyvinylidene chloride and polyvinyl chloride, and has a moisture vapor transmission rate that is selected to selectively control the transdermal permeation of said drug from said transdermal drug delivery system to achieve extended drug delivery over at least three days.