Physiological perturbations for measuring heart failure

摘要

Techniques of inducing a physiological perturbation to monitor a heart failure status of a patient are described. An implantable medical device (IMD) may induce a physiological perturbation in the patient to monitor and determine how the patient responds to the physiological change. This response may be indicative of heart failure improvement or worsening. For example, the IMD may deliver electrical stimulation with parameters configured to perturb the patient (e.g., stimulation that deviates from stimulation therapy). The IMD may then detect at least one physiological parameter to monitor the patient's response to the perturbation. Based on the detected physiological parameter, the IMD may generate a heart failure status. The heart failure status may then be used for adjusting patient therapy, with or without the use of remote monitoring.

主权项

1. A method comprising:
delivering an electrical stimulation therapy to a patient's heart defined by current therapy parameter values for treating a condition of the patient; inducing a physiological perturbation by:
delivering a baseline electrical stimulation to the patient's heart defined by an initial therapy delivered to the patient and comprising at least one baseline therapy parameter different than the current therapy parameters;after delivering the baseline electrical stimulation, inducing the physiological perturbation in the patient by delivering electrical stimulation to the patient's heart comprising a stimulation parameter having a perturbation value that deviates from a therapeutic value; detecting a physiological parameter in response to the induced physiological perturbation; comparing the physiological parameter to a physiological parameter detected during a previously induced perturbation; generating, by one or more processors, a heart failure status based on the detected change in the at least one physiological parameter; and adjusting the current therapy parameters used to deliver the electrical stimulation therapy in response to the generated heart failure status.