发明名称 Oxadiazole derivatives
摘要 The invention relates to oxadiazole compounds of formula I. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
申请公布号 US8815919(B2) 申请公布日期 2014.08.26
申请号 US201013260779 申请日期 2010.03.29
申请人 Merck Serono SA 发明人 Quattropani Anna;Montagne Cyril;Sauer Wolfgang;Crosignani Stefano;Bombrun Agnès
分类号 A61K31/4245;A61K31/197;C07D271/06 主分类号 A61K31/4245
代理机构 Saliwanchik, Lloyd & Eisenschenk 代理人 Saliwanchik, Lloyd & Eisenschenk
主权项 1. An oxadiazole derivative of Formula (AC)wherein R1, R2 independently denote H, Hal, CF3, OCF3, CN, NO2, OH, A, or OA, W is CH, Ry is CH3, F, Br, or Cl, G1 G2 independently from one another denote H, F, Br, Cl or CH3, with the proviso that one of G1 and G2 is other than H and that one of Ry, G1 and G2 is F, Br, or Cl, Rb is CH2OCH3, A is branched or linear alkyl having 1 to 12 C-atoms, wherein one or more 1 to 7 H-atoms may be replaced by Hal, OR3, COOR3, CN, N(R3)2 and wherein one or more 1 to 7 non-adjacent CH2-groups may be replaced by O, —NR3CO—, —CO— or S and/or by —CH═CH— or —C≡C— groups or cycloalkylene groups having 3 to 7 carbon atoms, or denotes cycloalkyl or cycloalkylalkylen having 3-7 ring C atoms, Hal is F, Cl, or Br, R3 is H or A; two geminal groups R3 together may form a ring with the atom they are attached to, Q-S denotes the following group:and pharmaceutically acceptable salts and stereoisomers thereof.
地址 Coinsins, Vaud CH