PICOLYL-2-AMIDES OF 1-R-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS EXHIBITING ANALGETIC ACTIVITY

摘要

The invention relates to chemico-pharmaceutical industry, in particular to bioactive substances such as amidated derivatives of quinoline carboxylic acid exhibiting analgetic activity.The inventions provides the prepatation of picolyl-2-amides of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids of general formula (1):,wherein R= -CHCHC=N (1a) or -CHCHCONH(1b),exhibiting analgetic activity.