Use of combination preparations comprising antifungal agents

摘要

The invention relates to the use of an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor for producing a combination drug for the topical treatment of Candida mycoses selected from vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush) and intertriginous (Candida) eczema.

主权项

1. A method of treating a Candida mycosis further defined as vulvovaginal candidiasis, oropharyngeal candidiasis (oral thrush), diaper dermatitis (diaper thrush), and/or intertriginous eczema comprising:
obtaining a combination drug comprising an antimycotic agent and an epithelial cell or endothelial cell adhesion inhibitor; and topically treating a subject having a Candida mycosis further defined as vulvovaginal candidiasis, oropharyngeal candidiasis, diaper dermatitis, and/or intertriginous eczema with the combination drug, wherein the epithelial cell or endothelial cell adhesion inhibitor is further defined as: a non-steroidal antiphlogistic agent (NSAID) having a sufficient COX1-inhibition, defined by the exclusion of compounds having a COX1/COX2 ratio (IC50, microM) of >20; a prostacyclin or a prostacyclin analogue; or an inhibitor of the expression of epithelial and endothelial adhesion molecules.