发明名称 |
Inhibiting striated muscle activator of RHO (stars) to improve glycemic control |
摘要 |
Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of Striated Muscle Activator of Rho Signaling (STARS) activity, and methods of identifying new compounds for use in the described methods of treatment. |
申请公布号 |
US8815799(B2) |
申请公布日期 |
2014.08.26 |
申请号 |
US201113701082 |
申请日期 |
2011.06.03 |
申请人 |
Joslin Diabetes Center, Inc. |
发明人 |
Patti Mary Elizabeth;Jin Wanzhu;Goldfine Allison B. |
分类号 |
C12N9/00;C12N15/82;C12N15/113 |
主分类号 |
C12N9/00 |
代理机构 |
Pierce Atwood LLP |
代理人 |
Pierce Atwood LLP ;Farrell Kevin M.;Wilson David J. |
主权项 |
1. A method for improving glycemic control in a subject in need thereof, the method comprising administering a therapeutically effective amount of an inhibitor of MLK1-dependent SRF transcriptional activity. |
地址 |
Boston MA US |