Pharmaceutical compositions and method of using levodopa and carbidopa

摘要

The present invention relates to stable dosage forms and compositions of levodopa and carbidopa for the treatment of patients suffering from Parkinson's disease. The dosage forms and compositions comprise both solid and liquid formulations and result in stable pharmaceutical products. Such dosage forms and compositions comprise a metal chelator and a levodopa concentration from about 1 mg/mL to about 30 mg/mL.

主权项

1. A pharmaceutical dosage form comprising an aqueous solution of levodopa, carbidopa, an acid, and a metal chelator, wherein the levodopa concentration is up to about 30 mg/ml, the molar ratio of levodopa to carbidopa is 3:1 to 25:1, and the solution exhibits a 7 day, 25° C. carbidopa degradation rate of less than 5%.