发明名称 Coumarin-chalcones as anticancer agents
摘要 The present invention relates to certain coumarin/chalcone compounds or a pharmaceutically acceptable salt thereof. The present invention particularly relates to the coumarin/chalcone compounds as anticancer agents useful for the treatment of cancer. The present invention also relates to the process of preparation of the said compounds.;
申请公布号 US8815940(B2) 申请公布日期 2014.08.26
申请号 US201113814401 申请日期 2011.08.05
申请人 Council of Scientific & Industrial Research 发明人 Sashidhara Koneni Venkata;Kumar Abdhesh;Kumar Manoj;Sarkar Jayanta;Sinha Sudhir Kumar
分类号 A61K31/35;C07D311/02 主分类号 A61K31/35
代理机构 Blank Rome LLP 代理人 Blank Rome LLP
主权项 1. A compound of general formula (VI) or a pharmaceutically acceptable salt thereof,wherein: R is selected from the group consisting of: H, CHO, COCH3, NHCOCH3, F, Cl, Br, NO2, CF3, OCF3, CH3, C2H5, C3H7, straight or branched alkyl chain up to six carbons, straight and branched alkoxy/sulphoxy chain up to six carbons, and phenyl and substituted phenyl ring, wherein the substituents in phenyl ring are selected from the group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5,C3H7, straight or branched alkyl chain up to six carbons, X is selected from the group consisting of: O, S, CH2, and NR3, wherein R3 ═H, CH3, C2H5, or C3H7, R1 is selected from the group consisting of: CH3, C2H5, C3H7, straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, pipendinyl, unsubstituted and substituted phenyl ring, wherein the substituents in phenyl ring are selected from the group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, and OCF3, R2 is selected from the group consisting of: CHO, and —CH═CHCOR4 wherein R4 is selected from the group consisting of: CH3, C2H5, C3H7, straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, heteroaryl, pipendinyl, thienyl, furyl, pyridyl, indolyl and phenyl, which may be unsubtituted or substituted by one, two or three substituents being independently selected from the group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, CF3, NMe2, NEt2, SCH3, and NHCOCH3.
地址 New Delhi IN