Methods of predicting musculoskeletal disease

摘要

This invention is directed to methods of predicting bone or joint disease in a subject. The invention is also directed to methods of determining the effect of a candidate agent on any subject's risk of developing bone or joint disease.

主权项

1. A method for assessing bone condition in a subject by obtaining information regarding one or more bone parameters from an image of the subject in a computer system, the method comprising:
(a) obtaining the image comprising image of a bone of the subject; (b) defining two or more regions of interest (ROIs) in the image; (c) analyzing a plurality of positions in the ROIs to determine one or more bone microarchitecture parameters and one or more bone macro-anatomy parameters; (d) combining the parameters into a numerical index; and (e) comparing the numerical index against a reference database.