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1. A compound of Formula (I) wherein the compound of Formula (I) is selected from the group consisting of a compound wherein Y is pyridin-2-yl, Z is (3-fluoro-4-phenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-phenylmethyl-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 3-(phenylcarbonyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(phenylcarbonyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is biphenyl-4-ylmethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 3-(4-fluoro-phenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 9H-fluoren-1-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is fluoren-9-on-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is biphenyl-3-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is quinolin-6-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 1H-indol-5-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 1,2,3,4-tetrahydro-quinolin-6-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 3-methyl-benzofuran-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-phenyl-furan-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(3-trifluoromethyl-phenyl)furan-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(4-methoxyphenyl)furan-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(phenylethynyl)furan-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(4-methyl-phenyl)furan-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(cyclohexylcarbonylamino)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (4-phenoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 1-propyl-indol-5-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(1-cyclohexyl-2,3-dihydro-1Hindol-5-yl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (4-azepan-1-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(cyclohexyl-methyl-amino)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(phenyl-methyl-amino)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(4-(cyclohexylmethyl-methylamino)phenyl)-ethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(1,1,4,4-tetramethyl-1,2,3,4-tetrahydro-naphth-6-yl)ethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(1,1-dimethyl-propyl)-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(4-t-butyl-phenyl)ethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(4-trifluoromethylthio-phenyl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(4-chloro-phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(4-chloro-phenyl)-1-(4-aminosulfonyl-phenyl)-1H-pyrazol-3-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(4-chloro-phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-phenyl-5-trifluoromethyl-oxazol-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-(phenylmethoxy)indol-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-phenylmethoxy-1H-indol-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-n-butyl-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (3-phenoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (4-phenylmethoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (2-phenylmethoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(isoindol-1,3-dion-2-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 6-methoxy-naphth-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 1,2-diphenyl-ethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is (3-phenoxy)phenylmethyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(1-t-butoxycarbonyl)piperidin-4-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-(1-t-butoxycarbonyl)piperidin-4-yloxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-phenoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-iodo-3-methyl-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (3-fluoro-4-phenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-phenylmethyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-t-butyl-cyclohexyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-n-pentyl-cyclohexyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(4-isopropyl-phenyl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(3-trifluoromethylphenyl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(biphenyl-4-yl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 5-n-butyl-pyridin-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is quinolin-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-phenyl-5-trifluoromethyl-thien-2-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 3-(1,3-dihydro-isoindol-2-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-iodo-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-iodo-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-phenylmethoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-iodo-pyridin-2-yl, Z is (4-phenylmethoxy)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-iodo-pyridin-2-yl, Z is (4-phenylmethyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 1-phenyl-1H-pyrazol-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 1,5-diphenyl-1H-pyrazol-3-yl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 4-diethylamino-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-(3-ethoxyphenyl)-vinyl, r is 1, and R2 is absent; a compound wherein Y is pyridin-2-yl, Z is 2-phenyl-1H-benzimidazol-5-yl, r is 1, and R2 is absent; a compound wherein Y is thiazol-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is benzothiazol-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is benzoxazol-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 5-bromo-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 3-iodo-4-methyl-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-chloro-3-iodophenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 3-iodo-4-methoxyphenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 2-(3-iodo-phenyl)ethyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 2-(4-iodo-phenyl)ethyl, r is 1, and R2 is absent; a compound wherein Y is 3-chloro-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 5-chloro-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is benzo[d]isoxazol-3-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 5-trifluoromethyl-1,3,4-thiadiazol-2-yl, Z is 4-cyclohexyl-phenyl, r is 1, and R2 is absent; a compound wherein Y is 1,3,5-triazin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 4-methyl-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-methyl-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-cyano-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 5-cyano-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 3-trifluoromethyl-pyridin-2-yl, Z is (4-cyclohexyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is oxo; a compound wherein Y is 4-methyl-pyridin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is 3-cyano-pyridin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is 3-trifluoromethyl-pyridin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is thiazol-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is benzothiazol-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is benzoxazol-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is 5-bromo-pyridin-2-yl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(4-fluorophenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(2-chlorophenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(3,4-dichlorophenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(3-trifluoromethylphenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(4-methoxyphenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-dimethylamino-phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-pyrrol-1-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-pyrazol-1-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-imidazol-1-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-pyrrolidin-1-yl)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 1-isopropyl-2-trifluoromethyl-1Hbenzimidazol-5-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 2-methyl-1-phenyl-1H-benzimidazol-5-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 1-cyclohexyl-2-methyl-1H-benzimidazol-5-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-nitrophenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(2-iodophenylmethylamino)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(5-iodo-furan-2-ylmethylamino)phenyl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 4-(4-iodophenyl)phenyl, r is 1, and R2 is absent; a compound wherein Y is 2-methoxyphenyl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is 2-methylthiophenyl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is 2-nitrophenyl, Z is biphenyl-4-yl, r is 1, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is biphenyl-4-yl, r is 2, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-pyrrolidin-1-yl)phenyl, r is 2, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is (4-phenylmethyl)phenyl, r is 2, and R2 is absent; a compound wherein Y is pyrimidin-2-yl, Z is 6-trifluoromethyl-benzothien-2-yl, r is 1, and R2 is absent; and enantiomers, diastereomers, and pharmaceutically acceptable salt forms thereof. |
