Methods and compositions for promoting bone and joint health

摘要

Methods and compositions that can be used to promote bone and joint health through amelioration, stabilization and repair of damage associated with various pathophysiological conditions are disclosed.

主权项

1. A method to promote bone and joint health in a mammal in need thereof, said method comprising administering to the mammal a composition comprising a therapeutically effective amount of berberine or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of a substituted 1,3-cyclopentadione compound selected from the group consisting of tetrahydroisoalpha acids and pharmaceutically acceptable salts thereof, wherein the berberine and the substituted 1,3-cyclopentadione compound are in synergistic amounts and in a synergistic ratio with combination index of less than 1 for synergistic inhibition of MMP-13 expression.