Clotting factor-Fc chimeric proteins to treat hemophilia

摘要

The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.

主权项

1. A method of treating a hemostatic disorder in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a chimeric protein, which comprises a first polypeptide and a second polypeptide, wherein the first polypeptide comprises (i) a clotting factor, which is Factor VII or Factor VIIa, and (ii) at least a portion of an immunoglobulin constant region fused to the clotting factor, which is a FcRn binding partner, and the second polypeptide comprises at least a portion of an immunoglobulin constant region, which is a FcRn binding partner, without the clotting factor of said first polypeptide and without an immunoglobulin variable domain, and wherein said first polypeptide and said second polypeptide are linked.