| 发明名称 | Methods for Preparing TACI-immunoglobulin fusion proteins | ||
| 摘要 | Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors. | ||
| 申请公布号 | US8815238(B2) | 申请公布日期 | 2014.08.26 |
| 申请号 | US201313956499 | 申请日期 | 2013.08.01 |
| 申请人 | ZymoGenetics, Inc. | 发明人 | Rixon Mark W.;Gross Jane A. |
| 分类号 | C12N15/00;C07H21/04;C12P21/04;C07K16/00 | 主分类号 | C12N15/00 |
| 代理机构 | Alston & Bird LLP | 代理人 | Alston & Bird LLP |
| 主权项 | 1. A mammalian host cell comprising a nucleic acid molecule construct encoding a fusion protein comprising (a) a first polynucleotide encoding a transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptor moiety, wherein the TACI receptor moiety consists of amino acid residue 30 to 154 of SEQ ID NO:2 and wherein the TACI receptor moiety binds at least one of ZTNF2 or ZTNF4; and, (b) a second polynucleotide encoding an immunoglobulin moiety that comprises a CH2 and a CH3 domain; wherein said first and said second polynucleotide encode said fusion protein. | ||
| 地址 | Seattle WA US | ||