| 主权项 |
1. A compound of the formula (I): in which Q is C(═O) or S(═O)2; X1 and X2 are each independently CH2 or CHR7,
where R7 is C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; m and n are each 1; R1is C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C1-8-alkyl-bridged C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C1-8-alkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; OR8; NR8R9;
NHC(═O)R8; NR8R9; or NH—S(═O)2R8;where R8 and R9 are each independently H; C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C1-8-alkyl-bridged C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C1-8-alkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or R1 is —NHCHRa(═O) —Rb where
Ra is selected from the group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, —CH2CH2SCH3, —CH2C6H5, —CH2-indolyl, —CH2OH, —CH(OH)CH3, —CH2C(═O)NH2, CH2CH2C(═O)NH2, —CH2—C6H4—OH, —CH2SH, —CH2CH2CH2CH2NH2, —CH2CH2CH2NHC(═NH)NH2, —CH2-imidazolyl, —CH2CO2H, and —CH2CH2CO2H; andRb is selected from —OH and -peptidyl, where the peptidyl is bonded covalently via its N terminus; R2 and R5 are each independently H; C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; R3 and R4 are each independently H; C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; R6 is H; C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C1-8-alkyl-bridged C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C1-8-alkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; C(═O)R10;
C(═O)OR10; C(═O)NR10R11; S(═O)2—R10; S(═O)2OR10; or S(═O)2NR10R11;where R10 and R11 are each independently H; C1-10-alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C1-8-alkyl-bridged C3-10-cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C1-8-alkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, where the alkyl chain in each case may be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or R6 is —C(═O)—CHRyNHRz where
Ryis selected from the group consisting of —H, —CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH(CH3)CH2CH3, —CH2CH2SCH3, —CH2C6H5, —CH2-indolyl, —CH2OH, —CH(OH)CH3, —CH2C(═O)NH2, CH2CH2C(═O)NH2, —CH2—C6H4—OH, —CH2SH, —CH2CH2CH2CH2NH2, —CH2CH2CH2NHC(═NH)NH2, —CH2-imidazolyl, —CH2CO2H, and —CH2CH2CO2H; andRz is selected from —H and —C(═O)—C1-8-alkyl; in which “alkyl substituted”, “heterocyclyl substituted” and “cycloalkyl substituted” on the corresponding radicals represents the substitution of one or more hydrogen atoms in each case independently by F; Cl; Br; I; NO2; CN; CF3; C1-8-alkyl; phenyl; C(═O)OH; C(═O)O—C1-8-alkyl; C(═O)O-phenyl; C(═O)NH2; C(═O)NH—C1-8-alkyl; C(═O)NH-phenyl; C(═O)N(C1-8-alkyl)2; OH; ═O; OCF3; O—C1-8-alkyl; O—C(═O)—C1-8-alkyl; SH; SCF3; S—C1-8-alkyl; S(═O)2OH; S(═O)2C1-8-alkyl; S(═O)2O—C1-8-alkyl; S(═O)2NH—C1-8-alkyl; S(═O)2N(C1-8-alkyl)2; NH2; NH—C1-8-alkyl; NH-phenyl; N(C1-8-alkyl)2; NH—C(═O)—C1-8-alkyl; NH—S(═O)2—C1-8-alkyl; in which “aryl substituted” and “heteroaryl substituted” on the corresponding radicals represents the substitution of one or more hydrogen atoms in each case independently by F; Cl; Br; I; NO2; CN; CF3; C1-8-alkyl; phenyl; C(═O)OH; C(═O)O—C1-8-alkyl; C(═O)O-phenyl; C(═O)NH2; C(═O)NH—C1-8-alkyl; C(═O)NH-phenyl; C(═O)N(C1-8-alkyl)2; OH; OCF3; O—C1-8-alkyl; O—C(═O)—C1-8-alkyl; SH; SCF3; S—C1-8-alkyl; S(═O)2OH; S(═O)2 C1-8-alkyl; S(═O)2O—C1-8-alkyl; S(═O)2NH—C1-8-alkyl; S(═O)2N(C1-8-alkyl)2; NH2; NH—C1-8-alkyl; NH-phenyl; N(C1-8-alkyl)2; NH—C(═O)—C1-8-alkyl; NH—S(═O)2—C 1-8-alkyl; in each case in the form of a free compound; of a racemic mixture; of an enantiomer, diastereomer, a mixture of the enantiomers or diastereomers, or of a single enantiomer or diastereomer; or in the form of a salt of a physiologically compatible acid or base. |
