6,7-disubstituted-sioquinoline derivatives and their use

摘要

The present invention relates compounds of general formula (I) and stereoisomers and pharmaceutically acceptable salts and prodrugs thereof; wherein R′ and R1-R5 are as defined in the claims. The invention also relates to said compounds for use as a medicament and particularly in the treatment of drug addiction and CNS related diseases.;

主权项

1. A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof; wherein the dotted line represents an optional bond; R′ is H, or R′ is absent, when the dotted line represent a bond; R1 and R4 are each independently selected from the group consisting of H, halo, lower alkyl, trifluoromethyl and trifluoromethoxy; R2 and R3 are both F, or one of R2 and R3 is F and the other is lower alkyl or trifluoromethyl; and R5 is selected from the group consisting of halo, lower alkyl, trifluoromethyl and trifluoromethoxy, or when the dotted line represents a bond, then R5 may also be H.