| 摘要 |
The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic complication, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G protein-coupled receptor (GPCR) in a patient. The compounds are of structure (I).; |
| 主权项 |
1. A compound having the formula:or a pharmaceutically acceptable salt thereof,wherein:
A is —O— or —N(R12)—; W is —C(O)O—, —C(O)— or —S(O)2—; —X—Y is CH2—CH2 or CH═CH; R3 is alkyl, haloalkyl or cycloalkyl, wherein the cycloalkyl group can be optionally substituted with up to 4 substituents each independently selected from the group consisting of: alkyl and halo; each occurrence of R7 is independently H or alkyl; R8 is aryl or heteroaryl, optionally substituted with R9; R9 represents from 1-4 optional substituents, which can be the same or different, selected from alkyl, alkenyl, alkynyl, halo, haloalkyl, —CN, —NO2, —O-(alkylene)t-R13, —S-(alkylene)t-R13, —N(R13)-(alkylene)t-R13, -(alkylene)t-R13, —C(O)-(alkylene)t-R13, —C(O)O-(alkylene)t-R13, —N(R7)C(O)-(alkylene)t-R13, —C(O)N(R7)-(alkylene)t-R13, —OC(O)-(alkylene)t-R13, —N(R7)C(O)N(R7)-(alkylene)t-R13, —N(R7)C(O)O-(alkylene)t-R13, —S(O)-(alkylene)t-R13 or —S(O)2(alkylene)t-R13; R12 is H, alkyl or aryl; each occurrence of R13 is independently H, haloalkyl, aryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl or heteroaryl; and each occurrence of t is independently 0 or 1. |
