Co-crystal intermediates of rosuvastatin and methods of using same

摘要

Methods for the preparation of Rosuvastatin by co-crystals of Rosuvastatin or intermediates are provided. Also provided are co-crystals, pharmaceutical compositions which include such co-crystals and methods for treating conditions associated with hypercholesterolemia by administering such compositions.

主权项

1. A method for preparing Rosuvastatin or its salts comprising:
(a) preparing a co-crystal of Rosuvastatin selected from the group consisting of:
1. Rosuvastatin 2-aminopyrimidine hemihydrate,2. Rosuvastatin pyrazine hydrate, and3. Rosuvastatin quinoxaline (1:2); and (b) converting the co-crystal prepared in step (a) to the Rosuvastatin of formula (I)or a salt thereof.