| 发明名称 | Methods and compositions for the inhibition of gene expression | ||
| 摘要 | The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers. | ||
| 申请公布号 | US8815599(B2) | 申请公布日期 | 2014.08.26 |
| 申请号 | US200511628424 | 申请日期 | 2005.06.01 |
| 申请人 | ProNAi Therapeutics, Inc. | 发明人 | Sheikhnehjad Gholamreza;Sooch Mina Patel;Goodwin Neal Clifford;Olson David |
| 分类号 | A61K48/00;A61K9/127;C12N15/88;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | Honigman Miller Schwartz & Cohn LLP | 代理人 | Honigman Miller Schwartz & Cohn LLP ;Murphy Kelly T.;O'Brien Jonathan P. |
| 主权项 | 1. A method of treating a cell capable of expressing a c-myc gene, wherein said cell is capable of proliferation, comprising a) providing an oligonucleotide that hybridizes to a promoter region of a c-myc gene wherein said oligonucleotide is selected from the group consisting of SEQ ID NOs: 110, 111, 113, 114, and 115; and b) introducing said oligonucleotide to said cell. | ||
| 地址 | Kalamazoo MI US | ||