Opiod agonist formulations with releasable and sequestered antagonist

摘要

Disclosed are oral dosage forms, comprising (i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in releasable form; and (iii) a sequestered opioid antagonist which is not released when the dosage form is administered intact, and methods thereof.

主权项

1. An oral dosage form comprising:
(i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in a releasable form; and (iii) an additional opioid antagonist combined with one or more pharmaceutically acceptable hydrophobic materials such that the additional opioid antagonist is substantially not released from the dosage form which is administered orally intact, wherein the opioid antagonist in the releasable form is naloxone or a pharmaceutically acceptable salt thereof, and at least one of the hydrophobic materials comprises a cellulose polymer or an acrylic polymer.