| 发明名称 |
ANTIGEN-BINDING MOLECULE HAVING REGULATED CONJUGATION BETWEEN HEAVY-CHAIN AND LIGHT-CHAIN. |
| 摘要 |
<p>It is found that the conjugation between CH1 and CL can be inhibited and a hetero molecule can be formed more efficiently than a case in which a mutation of introducing a knob and a hole singly into CH3 is employed when an amino acid residue present on the interface between CH1 and CL is substituted by an amino acid residue having an electrical charge.</p> |
| 申请公布号 |
MX2014005045(A) |
申请公布日期 |
2014.08.22 |
| 申请号 |
MX20140005045 |
申请日期 |
2012.10.31 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TOMOYUKI IGAWA;TAICHI KURAMOCHI;MEIRI KAWAZOE;NAOKA HIRONIWA |
| 分类号 |
C12N15/09;A61K39/395;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;C12P21/08 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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