发明名称 |
Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada que comprende pirfenidona; y su uso para el tratamiento o regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica. |
摘要 |
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-a and anti-TGF-²1 action for the treatment of hepatic fibrosis. |
申请公布号 |
CL2014000131(A1) |
申请公布日期 |
2014.08.22 |
申请号 |
CL20140000131 |
申请日期 |
2014.01.17 |
申请人 |
CELL THERAPY AND TECHNOLOGY, S.A. DE C.V. |
发明人 |
ARMENDARIZ BORUNDA JUAN;MAGAÑA CASTRO JOSE AGUSTIN ROGELIO;CERVANTES GUADARRAMA JORGE |
分类号 |
A61K9/16;A61K9/20;A61K31/4412;A61P13/00 |
主分类号 |
A61K9/16 |
代理机构 |
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