| 发明名称 |
LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS |
| 摘要 |
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide. |
| 申请公布号 |
US2014235700(A1) |
申请公布日期 |
2014.08.21 |
| 申请号 |
US201214346357 |
申请日期 |
2012.09.28 |
| 申请人 |
ECOLE NORMALE SUPERIEURE DE LYON ;INSTITUT NATIONAL DELA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
Girard-Gagnepain Anais;Verhoeyen Els;Lavillette Dimitri;Cosset François-Loïc |
| 分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:
a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide. |
| 地址 |
Lyon FR |
